ILA-technology
The advantages of our Implantable Local Anesthetics technology are threefold:
- easy and intuitive to use
- stays in place at the target site and dissolves over time
- controlled, sustained local drug delivery for days instead of hours.
Precise drug delivery
The hydrogel can be loaded with small-molecule drugs. Release profiles can be tailored to clinical needs and surgical procedures, including sustained local delivery during the critical first days after surgery.
Biodegradability
The hydrogel is composed of biopolymers and is designed for high biocompatibility. After release of the active pharmaceutical ingredient, the hydrogel undergoes complete non-acidic degradation.
Resilience
The combination of strength and elasticity enables co-implantation with surgical hardware, including pedicle screws. This resilience supports use under challenging conditions such as minimally invasive surgery, while keeping the surgical workflow unchanged.
Platform Potential
Spine is our first indication because of the extreme pain burden, prolonged length of stay, and high healthcare costs. The same ILA technology can be adapted to other orthopedic procedures where multi-day local drug delivery is desirable, including joint replacement and fracture fixation.
Initially tailored towards spine surgery, the platform is designed to be applied in other surgical indications, including joint replacements and fracture fixation.
Publications
- Jonkman HHR, van Tol FR, Govers TM, Debets SACA, Wainwright TW, Debono B, Yang MMH, Boer HD, Rovers MM, Verlaan JJ. Enhanced Recovery After Lumbar Fusion Surgery: An International Survey on Current Practice. Global Spine J. 2026
- Steverink JG, Bruins S, van Tol FR, Jonkman HR, Amponsah KB, Marvela J, Smorenburg AJ, Oosterman BJ, Piluso S, Verlaan JJ. Preclinical safety and feasibility of a bupivacaine-loaded hydrogel for pain relief after spinal surgery. Sci Rep. 2025
- Jonkman H, van Tol FR, Bruins S, Steverink JG, Benneker LM, Geuze R, de Baat P, Rovers M, Oosterman BJ, Verlaan JJ. Novel implantable anesthetic for spine fixation surgery: phase Ib safety results of a sustained-release formulation of bupivacaine. Reg Anesth Pain Med. 2025
- Steverink JG, van Tol FR, Bruins S, Amponsah KB, Marvela J, Smorenburg AJ, Jonkman HR, Oosterman BJ, van Dijk MR, Malda J, Piluso S, Verlaan JJ. Testing a new sustained-release local anesthetic formulation specifically designed for spine surgery in a sheep model. Int J Pharm. 2025
- Steverink JG, van Tol FR, Bruins S, Smorenburg AJ, Tryfonidou MA, Oosterman BJ, van Dijk MR, Malda J, Verlaan JJ. Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model. J Exp Orthop. 2023
- Steverink JG, van Tol FR, Oosterman BJ, Vermonden T, Verlaan JJ, Malda J, Piluso S. Robust gelatin hydrogels for local sustained release of bupivacaine following spinal surgery. Acta biomater., 2022.
- Steverink JG, Piluso S, Malda J, Verlaan JJ. Comparison of in vitro and in vivo Toxicity of Bupivacaine in Musculoskeletal Applications. Front. Pain Res., 2022.
- Steverink JG, Oostinga D, van Tol FR, van Rijen MHP, Mackaaij C, Verlinde-Schellekens SAMW, Oosterman BJ, Van Wijck AJM, Roeling TAP, Verlaan JJ. Sensory Innervation of Human Bone: An Immunohistochemical Study to Further Understand Bone Pain. J Pain., 2021.
- Oostinga D, Steverink JG, van Wijck AJM, Verlaan JJ. An understanding of bone pain: A narrative review. Bone., 2020.

